Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study| JOURNAL OF GERONTOLOGY AND GERIATRICS
Vol. 66: ISSUE 1 - MARCH 2018
Original investigation - until March 2020
Published: 2018-03-15
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Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study

System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy
System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy
Non-Invasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy
Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Fondazione Policlinico “Tor Vergata”, Rome, Italy; 3 AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Geriatric Section, Turin, Italy
Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Fondazione Policlinico “Tor Vergata”, Rome, Italy; 3 AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Geriatric Section, Turin, Italy
AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Neurology, Turin, Italy
AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Neurology, Turin, Italy
System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy
ASL TO1, Outpatient Neurology, Turin, Italy
PO Humanitas Gradenigo, Outpatient Neurology, Turin, Italy
PO Humanitas Gradenigo, Outpatient Neurology, Turin, Italy
AO Ordine Mauriziano, Outpatient Neurology, Turin, Italy
PO Cardinal Massaia, Outpatient Neurology, Asti, Italy
PO Cottolengo, Outpatient Neurology, Turin, Italy
PO San Giovanni Bosco, Outpatient Neurology, Turin, Italy
ASL TO5, Alzheimer Evaluation Unit, Moncalieri (TO), Italy
PO Abele Ajello, Outpatient Neurology, Mazara del Vallo (TP), Italy
PO Noale, Center for cognitive diseases and dementias CDCD Geriatric Section, Noale (VE), Italy
PO San Bassiano, Center for cognitive diseases and dementias CDCD Geriatric Section, Bassano del Grappa (VI), Italy
PO Santa Maria della Misericordia, Alzheimer Evaluation Unit Neurology and Neurorehabilitation, Udine, Italy
PO Santa Maria della Misericordia, Alzheimer Evaluation Unit Neurology and Neurorehabilitation, Udine, Italy
Regional center for the study of brain aging (CRIC), Selvazzano Dentro (PD), Italy
Regional center for the study of brain aging (CRIC), Selvazzano Dentro (PD), Italy
PO Treviso, Alzheimer Evaluation Unit Neurology, Italy
PO Cazzavillan, Center for cognitive diseases and dementias CDCD, Arzignano (VI), Italy
Center for mental health (CSM), Cinquefrondi (RC), Italy
ASL NA 2 Nord, Alzheimer Evaluation Unit Geriatric Section, Naples, Italy
ASL NA 3 Sud, Alzheimer Evaluation Unit Neurology, Naples, Italy
AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy
AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy
AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy
Homotaurine Mild cognitive impairment Alzheimer’s disease

Abstract

Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administration
of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive
impairment.
Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imaging
and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of
homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental
State Examination (MMSE).
Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline
expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001),
and in those with mMCI at month 4 (p < 0.05).
Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients.
Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment
for cognitive symptoms. Further research is however needed to clarify whether this compound could
influence the progression of cognitive decline.

Affiliations

A. Martorana

System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy

c. Motta

System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy

G. Koch

Non-Invasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy

M. Massaia

Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Fondazione Policlinico “Tor Vergata”, Rome, Italy; 3 AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Geriatric Section, Turin, Italy

S. Mondino

Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Fondazione Policlinico “Tor Vergata”, Rome, Italy; 3 AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Geriatric Section, Turin, Italy

I. Raniero

AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Neurology, Turin, Italy

A. Vacca

AOU Città della Salute e della Scienza, Alzheimer Evaluation Unit Neurology, Turin, Italy

F. Di Lorenzo

System Medicine Department, Clinica Neurologica-Memory Clinic, Università di Roma “Tor Vergata”, Rome, Italy

G. Cavallo

ASL TO1, Outpatient Neurology, Turin, Italy

E. Oddenino

PO Humanitas Gradenigo, Outpatient Neurology, Turin, Italy

E. Pavanelli

PO Humanitas Gradenigo, Outpatient Neurology, Turin, Italy

M. Maniscalco

AO Ordine Mauriziano, Outpatient Neurology, Turin, Italy

V. Montano

PO Cardinal Massaia, Outpatient Neurology, Asti, Italy

A. Mastropietro

PO Cottolengo, Outpatient Neurology, Turin, Italy

N.C. Bellia

PO San Giovanni Bosco, Outpatient Neurology, Turin, Italy

E. Ciravegna

ASL TO5, Alzheimer Evaluation Unit, Moncalieri (TO), Italy

M. La Rocca

PO Abele Ajello, Outpatient Neurology, Mazara del Vallo (TP), Italy

E. Vitale

PO Noale, Center for cognitive diseases and dementias CDCD Geriatric Section, Noale (VE), Italy

F. Lorico

PO San Bassiano, Center for cognitive diseases and dementias CDCD Geriatric Section, Bassano del Grappa (VI), Italy

B. Zacchettin

PO Santa Maria della Misericordia, Alzheimer Evaluation Unit Neurology and Neurorehabilitation, Udine, Italy

A. Scalise

PO Santa Maria della Misericordia, Alzheimer Evaluation Unit Neurology and Neurorehabilitation, Udine, Italy

A. Codemo

Regional center for the study of brain aging (CRIC), Selvazzano Dentro (PD), Italy

C. Gabelli

Regional center for the study of brain aging (CRIC), Selvazzano Dentro (PD), Italy

M. Spano

PO Treviso, Alzheimer Evaluation Unit Neurology, Italy

S. Poli

PO Cazzavillan, Center for cognitive diseases and dementias CDCD, Arzignano (VI), Italy

D. Panuccio

Center for mental health (CSM), Cinquefrondi (RC), Italy

P. Bruno

ASL NA 2 Nord, Alzheimer Evaluation Unit Geriatric Section, Naples, Italy

P. Alfieri

ASL NA 3 Sud, Alzheimer Evaluation Unit Neurology, Naples, Italy

R. Ruggiero

AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy

F. Cursi

AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy

G. Levi della Vida

AO San Camillo Forlanini, Outpatient geriatric clinic, Rome, Italy

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018

How to Cite

[1]
Martorana, A., Motta, c., Koch, G., Massaia, M., Mondino, S., Raniero, I., Vacca, A., Di Lorenzo, F., Cavallo, G., Oddenino, E., Pavanelli, E., Maniscalco, M., Montano, V., Mastropietro, A., Bellia, N., Ciravegna, E., La Rocca, M., Vitale, E., Lorico, F., Zacchettin, B., Scalise, A., Codemo, A., Gabelli, C., Spano, M., Poli, S., Panuccio, D., Bruno, P., Alfieri, P., Ruggiero, R., Cursi, F. and Levi della Vida, G. 2018. Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study. JOURNAL OF GERONTOLOGY AND GERIATRICS. 66, 1 (Mar. 2018), 15-20.
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