Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study
Background & Aims. This observational retrospective study aimed at evaluating the effects of one-year administration of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive
Methods. Patient’s demographic data and medical history are reported. Each patient performed brain imaging
and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of
homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental
State Examination (MMSE).
Results. 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline
expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001),
and in those with mMCI at month 4 (p < 0.05).
Conclusions. Administration of homotaurine revealed beneficial effects in our sample population of MCI patients.
Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment
for cognitive symptoms. Further research is however needed to clarify whether this compound could
influence the progression of cognitive decline.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018
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