Age, mitochondria and bladder cancer| JOURNAL OF GERONTOLOGY AND GERIATRICS
Vol. 66: SPECIAL ISSUE 4 - DICEMBER 2018 - Urologic problems in elderly patient
Translational Research in Gerontology and Geriatrics - Reviews
Published: 2018-12-15
PDF

Age, mitochondria and bladder cancer

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy
CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy
Department of Clinical and Experimental Medicine, University of Foggia, Italy
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Urology Unit, ASST-Ospedali Civili, Brescia, Italy
Department of Urology, Institut Montsouris, Paris, France
Aging Bladder cancer Oxidative stress Mitochondrial dysfunction

Abstract

Bladder cancer (BC) is a major cause of mortality worldwide. Risk factors for BC development are male gender,
age and exposure to carcinogens and especially cigarette smoking. Since it is not clearly understood why
aging is an important BC risk factor, in this review we try to find common features between BC and aging.
Evidence suggest that oxidative stress and mitochondrial dysfunction may link aging to BC, thus opening new
perspectives in terms of preventive measures and novel potential therapeutic targets.

Affiliations

A. Cormio

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy

C. Musicco

CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy

V. Pesce

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy

R. Villani

Department of Clinical and Experimental Medicine, University of Foggia, Italy

A. Antonelli

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Urology Unit, ASST-Ospedali Civili, Brescia, Italy

E. Barret

Department of Urology, Institut Montsouris, Paris, France

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018

How to Cite

[1]
Cormio, A., Musicco, C., Pesce, V., Villani, R., Antonelli, A. and Barret, E. 2018. Age, mitochondria and bladder cancer. JOURNAL OF GERONTOLOGY AND GERIATRICS. 66, 4 (Dec. 2018), 260-264.
  • Abstract viewed - 150 times
  • PDF downloaded - 56 times