Multiparametric magnetic resonance imaging/transrectal ultrasound fusion-guided prostate biopsy: a comparison with systematic transrectal ultrasound-guided prostate biopsy| JOURNAL OF GERONTOLOGY AND GERIATRICS

Abstract

Background & Aims. Prostate biopsy is the standard method for diagnosing prostate cancer. Herein we compared
the cancer detection rate of extended systematic Transrectal Prostate Biopsy with that of multiparametric
Magnetic Resonance Imaging/Transrectal ultrasound fusion-guided Prostate Biopsy.
Methods. Outcomes of 99 fusion prostate biopsy (Group A) were compared with those of a matched population
of patients having undergone systematic transrectal prostate biopsy (Group B) in the same period.
Results. The overall cancer detection rate was 60.6% in Group A and 29,2% in Group B (p = < 0,001) whereas
the rate of clinically-significant prostate cancer was 26.2% in Group A and 13,1% in Group B (p = 0,02). At first
prostate biopsy the above-mentioned rates were 76% in Group A and 31,9% in Group B (p < 0,001), whereas
in repeated biopsy the rates were 34,7% in Group A and 18,6% in Group B (p = 0,08). Cancer detection rates
correlated well with the Prostate Imaging-Reporting and Data System; in the setting of first biopsy, it was 84,6,
67,8, 100% for score 3, 4 and 5, respectively, whereas in the setting of repeat biopsy it was 28,5, 55,5 and 80%
for score 3, 4 and 5, respectively. Complications rate was similar in both groups but all occurred in patients
> 75y.
Conclusions. Multiparametric Magnetic Resonance Imaging/transrectal ultrasound fusion-guided biopsy provided
better prostate cancer detection rates than standard Prostate Biopsy in the setting of both first and
repeated Prostate Biopsy, showing good correlation between Prostate Imaging-Reporting and Data System
scores and cancer detection rates but complications were more common in elderly patients.