Clinical Geriatrics - Reviews
Submitted: 2020-07-22
Published: 2020-06-15

The secretory senescence of the senses of smell and taste

Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy
Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy
“Fisioter srl” Clinical Centre, San Salvo, Italy
“Fisioter srl” Clinical Centre, San Salvo, Italy
“Casa di Cura Liotti”, Clinical Centre, Perugia, Italy
Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy
aging smell taste nose salivary glands drugs chemotherapy radiotherapy


Aging is a progressive and multifaceted event, which involves all the cells and organs of the human body. In this chapter we will try to analyze how the senses of smell and taste change with age. Anatomical and physiological modifications of the nose and salivary glands will be described, as well as changes in structures of the Central Nervous System and neurochemical processes that underlie these two senses. Finally, we will discuss the effect of many senile age drugs and chemo- radiotherapy on the perception of smell and taste, as well as the impact of chronical diseases on these senses.


Aging is a physiological process, which has been widely studied for many human body systems and in different species 1. As concerns the sense of smell, researchers have not developed a unified model to explain the age-related modifications 2. The term “presbynasalis” has been introduced to describe the aging process of the nose and its functions.

The nose is a dynamic organ. Different conditions can influence the air flow pattern, modifying the nasal turbinate engorgement and the nasal secretory activity: air temperature and humidity, environmental factors (allergens, chemical molecules, infectious agents, air pollution, tobacco smoke), as well as physical activity and psychological stress.


Anatomical age-related modifications have been well documented. Cartilage becomes thinner and less elastic with age; in addition, the facial muscles weaken and undergo atrophy. As a result, the nose tip is not well supported and tends to fall. A progressive retraction of the columella is also observed.

Physiological changes, such as thickening of the nasal secretions and reduced ciliary-beat frequency can adversely affect the airflow. In 2001, Ho et al. studied the nasal mucosa of a group of healthy volunteers aged from 11 to 90 years, evaluating the muco-ciliary clearance time, the ciliary-beat frequency, and the ultrastructure of respiratory cilia. A significantly slower ciliary-beat frequency and longer muco-ciliary clearance time were observed in the subjects older than 40 years. These changes may help to explain the frequent occurrence of respiratory infection in the elderly 3.

The anatomical and physiological modifications mentioned above are more accentuated in patients with chronic rhinosinusitis and nasal polyposis, conditions that seem to prevail in older age 4.

In 2007, a prospective study evaluated the objective and subjective surgical outcomes in patients who underwent endoscopic surgery to treat chronic rhinosinusitis with nasal polyposis (CRSwNP), finding better postoperative results in the geriatric group than in the paediatric and adult groups. The authors assess that the decreased rate of mucosal regeneration, typical of the elderly, can play a role in preventing polyp recurrence; however, in these patients a longer healing period is required 5. In a 2012 study, Hong et al. assert that the impairment of epithelial barrier function persists and may worsen with age; this may contribute to explain the increasing incidence of nasal polyposis in the elderly population. Olfactory dysfunction is common in CRSwNP patients; in 2019, Gelardi et al. suggest that the clinical-cytological grading (CCG) may be useful in the work-up of CRSwNP patients, with a CCG score > 4, suggesting an olfactory impairment 6.

Changes in the composition of the nasal mucus can result in olfactory dysfunction, as the odorous particles need to be dissolved to interact with the olfactory receptors. A clear, anterior rhinorrhoea is commonly observed in older adults; it is widely known as “senile rhinorrhoea”. In a 2015 study, Rodriguez et al. found that this condition is significantly more frequent and more intense in the older subjects; the incidence of rhinorrhoea was independent from sex. Subjects who complained of a more frequent nasal drip appeared to be more bothered by this condition and, therefore, more interested in pursuing therapy. The aetiology of rhinorrhoea of aging is not well known. With aging, the activity of the sympathetic system increases; however, the alpha-receptors and beta-receptors are less sensitive. This could result in a decreased sympathetic tone. A continuous parasympathetic stimulation leads to an increased glandular secretion in the nose 7.

On the other hand, it is not uncommon to observe a reduction of the aqueous component of the nasal mucus in elderly individuals. Increased viscosity, reduced muco-ciliary clearance capacity and structural changes in the blood vessel wall may impair the air warming and the mucosal moisturizing processes, leading to nasal dryness and irritation 8.


The mucosal blood flow decreases with age; thus, the nasal epithelium becomes atrophic, thinner, and less elastic 8. Changes are also evident within the cribriform plate: aging leads to the progressive occlusion of the foramina, thus the olfactory cell axons can be damaged by gradual compression; this may result in cell necrosis. There is evidence that the density of receptor cells in the olfactory epithelium decreases with age; the olfactory mucosa is gradually replaced with respiratory epithelium. Studies performed on rats suggest that the mitotic activity of olfactory receptor cells decreases with age. A schematic drawing of the olfactory system can be seen in figure 1.

Other factors determining olfactory dysfunction are a progressive impairment of the immunologic and enzymatic defence mechanisms and the cumulative effect of the exposition to environmental factors (chemical agents, air pollution, tobacco smoke, allergens, etc.) throughout the lifespan.

Histological studies performed on autopsied olfactory bulbs found a global thinning and a reduction in the number of glomeruli in older subjects. Bulbar modifications seem to be consequent to the epithelial modifications; within the glomeruli, an increased number of synapses per olfactory cell was documented in older rats, thus suggesting a compensatory reaction.

Age-related volume reduction in human olfactory bulb was documented in vivo using magnetic resonance (MR) imaging. However, these findings cannot be considered as specific for aging, as they can be found also in cigarette smokers and other conditions such as congenital anosmia, chronic sinusitis, nasal polyposis, as well as in neurodegenerative diseases, acute depression, epilepsy and multiple sclerosis. This suggests that olfactory bulb volume may be a non-specific indicator of the olfactory function 9.


It is well known that aging leads to a reduction in brain weight, thickness of the cerebral cortex, and synaptic activity. The brain processing of olfactory information is also compromised. Functional imaging studies, performed with MR and positron emission tomography, documented a decreased activity in central olfactory pathways after odorous stimulation in elderly individuals. All these modifications contribute to explain the deterioration of the sense of smell over the years 9.

Impaired olfactory function is a peculiar feature of two Lewy body disorders: dementia with Lewy bodies and Lewy body Parkinsonism. For both disorders, neurons of the olfactory system are among the first to present the typical histopathological changes. Furthermore, Lewy bodies were observed in the brains of old subjects who died without Parkinson’s disease or dementia; this may suggest a possible preclinical stage in Lewy body disorders.

In 2011, Wilson et al. investigated the correlation between the age-related olfactory dysfunction and the autoptic findings of Lewy bodies in different brain regions. They tested the ability to identify familiar odours in more than 200 elderly individuals. Upon death, Lewy bodies were found in the brain of those with olfaction dysfunction. Although impaired olfaction has been recognized as a symptom of Lewy body disorders, to date the contribution of Lewy bodies to olfactory dysfunction in people without Lewy body disorders is not well understood. The Authors suggest that olfactory tests may be useful to the early detection of Lewy body disorders, in addition to clinical examination, neuroimaging studies and biologic markers 10.


With age, important neurochemical changes have been observed in the brain, concerning numerous enzymes, neurotransmitters, and neuromodulator systems. Physiologically, most of the age-related neurochemical decline occur before the age of 60 years; it means that, in case of neurodegenerative diseases, significant neurochemical changes have still happened at their onset. Among the neurotransmitters, acetylcholine is intimately involved in the modulation of olfactory function, as it plays a role in the synchronization of odour-induced activity from the olfactory bulb to the piriform cortex and facilitates odour learning and memorization.

Cholinergic neurons have a double function. On the one hand, they directly modulate neural activity within the olfactory bulb; on the other hand, with the contribution of other neurotransmitters, they tonically inhibit the activity of microglial cells, which are the innate immune effector cells of the Central Nervous System (CNS). Alterations in such modulation can lead to the release of inhibition on the microglial cells, resulting in the production of inflammatory mediators and neuronal damage 9.


A number of genes have been found to contribute to the age-related decline in odour identification.

In 2010, Hedner et al. studied the impact of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on age-related olfactory decline. BDNF is a neurotrophin family growth factor, which supports neuronal survival, transmission, and synaptic plasticity in the CNS. The carriers of the val homozygote allele exhibit a marked age-related impairment in olfactory function, whereas the val66met polymorphism seems to be protective against accelerated olfactory decline in elderly 11.

Calhoun-Haney and Murphy examined the olfactory function and the cognitive status in non-demented elderly individuals with the epsilon4 allele of the human apolipoprotein E gene (epsilon4+) 12. Apolipoprotein E is a plasma protein involved in lipid transport; its allelic variant epsilon4 has been associated with late onset familial and sporadic Alzheimer’s disease 13.

When retested after four years, the epsilon4+ subjects exhibited a significant decline in odour identification but not in odour threshold, picture identification or global cognitive status. Authors relate these findings to the impairment of the cortical areas associated with semantic memory for odours 12.


The olfactory perception can be studied through psychophysical tests (e.g., tests of odour detection, identification, discrimination, memory, and suprathreshold intensity), electrophysiological tests (e.g., odour event-related potentials), and psychophysiological tests (e.g., odour-related changes in heart rate and respiration) 9. Olfactory tests can be classified as subjective tests, based on the subjective response of the patient, or objective tests, that record physiological changes after olfactory stimulation.

The first steps towards the olfactometry were moved by the physiologist Valentin in 1842, and, fifty years later, by Passy who investigated the structure of the odorants. At the end of the nineteenth century Zwaardemaker, famous for his statement “we live in a world of odour like the world of sight and sound”, designed a simple instrument to measure the olfactory threshold, which consisted of a short kaoline tube with some odorous capsules inside.

The greatest development in olfactory testing occurred in the last thirty years. For many years, the most used test has been the University of Pennsylvania Smell Identification Test (UPSIT), conceived by Doty et al. in 1984. It consists of 40 microencapsulated odours (“scratch and sniff”) and can be self-administered. The result is normalized with respect to the patient’s age and gender; finally, the patient is categorized as normosmic, anosmic or hyposmic.

In 1988, Cain et al. introduced the Connecticut Chemosensory Clinical Research Center Test (CCCRCT), which consisted of a threshold test and an identification test.

In order to overcome the cultural differences and make the test available also in Europe, in 1996 Doty modified the UPSIT, changing the odorous stimuli according to the tradition and culture of different populations. Thus, the Cross-Cultural Smell Identification Test (CC-SIT) was designed; it consists of 12 odours that the patient should identify, choosing between different options.

In 1997, Hummel introduced in Europe the Sniffin’ Sticks (SS) (figure 2) test; it is a psychophysical test that allows a semi-objective assessment of the patient’s olfactory performance. The SS test, unlike UPSIT, cannot be self-administered. It requires particular felt pens, with the tips impregnated with odorant fluid. Each pen must be submitted only once, for 3 or 4 seconds, positioned about 2 cm from the edge of the nostril. The SS test consists of 3 subtests: the threshold test, the identification test and the odour discrimination test. It results in 4 scores: threshold score (T), discrimination score (D), identification score (I) and global olfactory score (TDI), which is the sum of the previous three 14.

Nowadays, Mazzatenta and colleagues have developed several systems to objectively investigate the olfactory perception using the Olfactory Event-Related Potentials and the Exhaled Organic Volatile Compounds. These tests return a crucial link between neurophysiology of perception and metabolic physiology 15-19.


It has been documented that 50% of patients aged between 65 and 80 years exhibits smell impairment; the percentage rises to 75% if a population older than 80 years is considered 9. The most worrying data emerging from a 2002 study is that almost all the subjects suffering from olfactory disorders are not aware of it: only 9.5% complained of smell changes in self-reporting tests 20.

Undoubtedly, olfactory impairment compromises the quality of life. First of all, subjects complain of a decreased taste ability, as the flavour is perceived thanks to the senses of taste and smell. The lack of the hedonistic component may contribute to malnutrition in the elderly.

Another fundamental aspect is a reduced perception of danger. Recent studies have shown that among patients with olfactory deficits, 37% experienced a dangerous smell-related event, such as a gas leak or food burned while cooking. Among individuals with normal smell, the percentage drops to 19% 9.


The sense of taste originates from the interaction of molecules, present in food or drinks, with the taste sensory cells, placed in the surface of the tongue, but also in the palate, pharynx, and larynx. The five main flavours (salty, acid, sweet, bitter and umami) are induced by chemical stimuli; each one is detected by the gustatory cells with a different molecular mechanism of transduction. The end organ of the sense of taste is the gustatory bud, a spherical cluster of receptor cells located in the epithelium of the tongue (figure 3). The taste cells are renewed often, with an average life of two weeks, and are regenerated by basal cells. Taste is closely related to the sense of smell. Food and drinks also stimulate the sense of smell by means of volatile molecules that reach the olfactory epithelium through the nasopharynx.

Saliva is the first secretion produced by the gastrointestinal system. Thanks to its lubricating and rheological properties, it participates to oral processing of food, it allows swallowing, facilitates speech, and has a role in food flavour perception. Indeed, in order to reach the taste receptors, all non-volatile food components need to be dissolved in the saliva. Furthermore, saliva secretion ensures continuous hydration of the mouth and have an antibacterial function thanks to lysozyme, lactoferrin, peroxidase systems, sIgA, histatins and mucins contained inside.

The major salivary glands – parotid, submandibular and sublingual glands – produce 95% of saliva. The remaining 5% is produced by the minor salivary glands, distributed in the palate, cheeks, tongue, and lips. Salivary glands secrete about 1-1.5 liters of saliva per day in adults.

Saliva is primarily produced in the acinar cells, which can be distinguished in serous cells – secreting digestive enzymes such as ptyalin – and mucous cells producing mucin, which consists of glycoproteins of various molecular weight. Acinar cells determine the type of secretion in the different glands; the parotid glands are serous secretion glands; minor salivary glands have mucous secretion; sublingual and submandibular glands have mixed serous and mucous secretion 21.

Salivary glands activity is regulated by the Autonomic Nervous System (ANS). Both parasympathetic and sympathetic systems stimulate salivary secretion, although the parasympathetic system has a greater action.

Ageing affects the ability to taste for several reasons. Physiological changes in salivary glands lead to their progressive hypofunction. Several systemic diseases such as diabetes, hypertension and Sjogren’s syndrome, as well as drugs, radiotherapy, and chemotherapy can lead to salivary gland dysfunction since these factors can compromise blood perfusion and are responsible for histological gland damage. Other causes of the age-related taste loss are a decline in cognitive function, a decreased number of taste and smell receptors, a reduced gland stimulation by the ANS. All these factors, in addiction to impaired chewing ability due to teeth loss, may result in reduced nutrient intake and malnutrition.


In parotid and submandibular glands ageing seems to lead to atrophy of the functional parenchyma, which is replaced with connective tissue and fat. The number of ducts remains constant. Conversely, the minor salivary glands do not exhibit fatty degeneration; atrophy of the parenchymal component is replaced with an increase in the fibrovascular component and in the number of ducts.

These histological changes result in overall salivary gland hypofunction 21.


Ageing alters both quantity (flow rate) and quality (ion and protein composition, rheology, tribology) of salivary secretions.

Several studies investigated the age-related changes in salivary flow rate. As reported by Xu et al. in their 2018 review, the findings are inconsistent, probably due to the wide variability in study design and saliva collection method among the different centers. Interestingly, a 2015 meta-analysis of 47 published reports, relating aging to salivary secretion, revealed that both unstimulated and stimulated average saliva flow rates were significantly lower in older adults than younger. Such a decrease seems to result from a lower activity of submandibular and sublingual glands, as parotid and minor salivary gland flow rates did not appear to be significantly lower.

Researchers agree that the use of multiple medications in the elderly population, such as antidepressants, diuretics, analgesics, antihistamines, antihypertensives and antianxiety drugs, does not fully explain the differences in salivary flow rates between younger and older adults. The determinant factors seem to be the age-related histological modifications in salivary glands, as described above. Such a decrease in salivary flow rate indirectly influences the quality of saliva 21.


Saliva is essentially made up of water (99.5%), electrolytes, organic components, and enzymes.

Studies on salivary composition in healthy elderly people are relatively scarce, since most of the works concerns patients with burning mouth syndrome, Sjögren’s Syndrome, or patients who underwent radiotherapy 21.

In a 2005 study, Nagler and Hershkovich found a significant increase in concentration of both organic and inorganic salivary components in healthy elderly individuals as compared to young population; they related this data to the age-dependent reduction of the salivary flow rate. As concerns the organic components, in addition to the salivary concentration, they also measured the total amount secreted into the oral cavity, concluding that in the elderly the total values of most salivary components decrease parallel to the salivary flow rate 22.

In 2014, Nassar et al. found a decrease in salivary calcium level in elderly people compared to young 23. Conversely, Sevon et al. reported elevated levels of salivary calcium in elderly women, with a peak at around the age of 50 years, compared to that of young women. In authors’ opinion, this data can be related to a lower bone density in elderly women 24.

However, since these studies do not use standardized age categories, the variety of the age ranges could have a significative impact on the results 21; furthermore, Sevon’s study regards women only, instead the other studies examine both sexes.

Interestingly, in literature there is consensus about the reduction of salivary mucin concentration with aging 21. Among mucins, the membrane-associated and the secreted soluble mucins can be distinguished. The first (MUC1, MUC3, MUC4, MUC12) form an immobile pellicle on the apical surface of epithelial cells and act as a barrier. The others (MUC2, MUC5A, MUC5B, MUC6, MUC7) form a mobile salivary film. A decrease in MUC1 and MUC2 salivary secretion has been reported in elderly subjects. Mucins provide an efficient barrier against the penetration of injurious substances into the epithelial cells as well as dryness. The lack of mucins may significantly affect oral health in elderly population 22. Studies on dry mouth patients’ saliva show lower levels of MUC5B and MUC7 that are responsible for altered rheological properties and for a reduced mucosal hydration 21.

In healthy elderly subjects, a lower lactoferrin and peroxidase activity has been reported, as well as reduction of sIgA, kallikrein and lysozyme, which result in weakened immunological and enzymatic defense 25.

As concerns the salivary bicarbonate, the findings are not consistent. A 2003 study investigated the concentration of electrolytes in stimulated whole saliva in individuals with hyposalivation; lower levels of bicarbonate, the main salivary buffer, were reported in elderly people 26. On the other hand, in their 2014 study Nassar et al. assessed that the salivary buffering capacity is not related to age. As most of the salivary bicarbonate is secreted by the parotid gland, the parotid gland function seems to be not prejudiced by aging 23.

A lower salivary concentration of basic fibroblast growth factor (bFGF) has been reported in elderly subjects. bFGF is involved in wound healing and tissue repair. The salivary concentration of bFGF varies with age, with the highest levels among young individuals and low levels in elderly. Since the bFGF has a key role in the maintenance of mucosal integrity, these values may reflect the age-dependent mucosal degeneration in the upper digestive tract 27.

A recent study of Maciejczyk et al. evaluated the efficiency of antioxidant systems in non-stimulated and stimulated saliva and in blood samples of healthy individuals of different ages, finding a progressive weakening in the elderly. In physiological conditions, an increased production of free radicals is compensated by antioxidant systems, which prevent oxidative damage to cellular components. However, a long-term overproduction of oxygen free radicals disturbs the redox balance, in favour of oxidation reactions in intracellular lipids, proteins and nucleic acids. These processes play a key role in the pathogenesis of many diseases as well as in the aging process 28.


It is well recognized that the taste sensitivity decreases with age 29. Some studies performed on mice found a reduction in the number of taste buds as a function of age 21. Conversely, other researchers rather relate the decreased taste sensitivity to a time lag in the turnover of taste receptor cells in the elderly.

In 2010, Kennedy et al. found significant differences in both detection and recognition thresholds and the correct identification of the basic taste of sweetness between young and older adults 29. It is well known that the sweetness perception is pH-dependent. As the food components need to be dissolved within the saliva to reach the taste receptors, changes in salivary inorganic composition resulting in salivary pH changes, may elevate the taste thresholds and decrease supra-threshold intensities. This may explain the taste aberrations and might consequently affect food intake in elderly 21. However, the age-associated taste impairment results less profound than the olfactory impairment 30.


The taste sensation, as well as the olfaction, may be modified by medicinal use, as shown in Tables I and II.

The high prevalence of chronic diseases in the elderly is responsible for polypharmacy, i.e. use of multiple medications. Hundreds of drugs have been reported to induce unpleasant tastes and/or odours as well as altered chemosensations; other medications affect the salivary secretion through an anticholinergic activity. The chemosensory side effects of drugs are due to the properties of the drug itself, such as molecules inducing bitter or metallic taste, or more frequently to their interaction with biochemical targets, with consequent alterations in the transduction pathway.

With chronic use, drugs can accumulate into the taste buds to levels high enough to induce a bitter taste 31. The accumulation is also due to hyposalivation which physiologically occurs in the elderly. In addition, hyposalivation can be amplified by xerostomia-inducing medications, such as psychotropic and diuretic agents 32.


The chemosensory system is more vulnerable to cytotoxic chemotherapy drugs than other sensory systems, probably due to the fast renewal of the gustatory and olfactory cells. In addition to these physiological changes, cognition is also altered: patients exhibit difficulties in gustatory and olfactory recognition and overall hedonic appreciation 33.

As concerns patients with head and neck cancer, radiotherapy can lead to taste disturbances even when the irradiation field is not focused on the oral cavity. The most affected gustatory cells result to be those responsible for the detection of sweet, bitter, and sour sensations. Interestingly, the gustatory disturbances seem to be a consequence of the radiation-induced apoptosis in the taste buds, rather than xerostomia. A 2019 study revealed that patients who underwent radiotherapy for head and neck cancer returned to a normal gustatory function three months after radiotherapy, even though they continued to report xerostomia 34.


Aging affects smell and taste perception for several reasons. With age, physiological changes in nasal mucosa and salivary glands lead to their progressive hypofunction. Several systemic diseases such as diabetes, hypertension and Sjogren’s syndrome, and radio-chemotherapy can compromise blood perfusion and are responsible for histological damage. Senile smell and taste loss is also due to a decline in cognitive function, a decreased number of receptors, and a reduced secretory stimulation by the ANS with age. All these factors may expose the elderly people to the risk of malnutrition, due to a reduced nutrient intake, and to life-threatening situations. We retain that more efforts should be undertaken in the scientific field to safeguard the elderly people and their health.

Figures and tables

Figure 1.Synaptic connections in the olfactory bulb.

Figure 2.The Sniffin' Sticks Test.

Figure 3.The gustatory bud.

Drug class Drug
Antihistamines agents Loratadine
Anti-inflammatory and analgesic agents AspirinDiclofenacIbuprofenTramadol
Antilipidemics Simvastatin
Cardiovascular agents FurosemideHydrochlorothiazideLisinoprilLosartanMetoprololPropranololSpironolactoneTriamterene
CNS drugs Amphetamine
Endocrine and diabetes drugs GlipizideInsulinMetformin
Gastrointestinal drugs OmeprazoleRanitidine
Psychopharmacologic agents AmitriptylineBupropionCitalopramFluoxetineParoxetineSertralineTrazodoneVenlafaxineAlprazolamClonazepamDiazepamZolpidem
Pulmonary agents Albuterol
Table I.Drugs inducing taste disorders.
Drug class Drug
Antihypertensives AmlodipineDiltiazemEnalapril
Anti-infectives AmoxicillinAzithromycinCiprofloxacin
Antilipidemics AtorvastatinLovastatinPravastatin
Corticosteroids Fluticasone
Endocrine drugs Levothyroxine
Table II.Drugs inducing taste and smell disorders.


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Krizia Piccininni

Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy

Francesco Barbara

Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy

Carlo De Luca

“Fisioter srl” Clinical Centre, San Salvo, Italy

Giulia De Luca

“Fisioter srl” Clinical Centre, San Salvo, Italy

Carmelo Zappone

“Casa di Cura Liotti”, Clinical Centre, Perugia, Italy

Silvana Ciccarone

Department of Otorhinolaryngology “Mons. Dimiccoli” Hospital, Barletta, Italy


© Società Italiana di Gerontologia e Geriatria (SIGG) , 2020

How to Cite

Piccininni, K., Barbara, F., De Luca, C., De Luca, G., Zappone, C. and Ciccarone, S. 2020. The secretory senescence of the senses of smell and taste. JOURNAL OF GERONTOLOGY AND GERIATRICS. 68, 02 Special (Jun. 2020), 91-98. DOI:
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