TY - JOUR AU - Mangiatordi, A. AU - Auciello, M. AU - Stallone, G. AU - Saita, A. AU - Hoznek, A. AU - Cormio, L. PY - 2018/12/15 Y2 - 2024/03/28 TI - Is percutaneous nephrolithotomy effective and safe in elderly patients? Outcomes of a case-control study JF - JOURNAL OF GERONTOLOGY AND GERIATRICS JA - Gerontology and Geriatrics VL - 66 IS - 4 SE - Clinical Geriatrics - Original Investigations DO - UR - https://www.jgerontology-geriatrics.com/article/view/66 SP - 173-177 AB - Background and aims. Percutaneous nephrolithotomy is the recommended treatment option for large orotherwise complex renal or proximal ureteral stones. Being a challenging procedure, its efficacy and safetyin elderly patients is questioned. The present study aimed to determine the impact of age on percutaneousnephrolithotomy outcome, comparing patients < 70y with those ≥ 70y.Methods. We analysed our prospectively maintained Internal Review Board approved database on percutaneous nephrolithotomy to compare demographics, perioperative outcomes and postoperative complications of patients < 70y with those of patients ≥ 70y.Result. Among 638 patients treated between April 2005 and March 2018, 553 were < 70y and 85 were ≥ 70y.There was no difference between the two populations in all preoperative characteristics but American Societyof Anaesthesiologists score, which was significantly worse in elderly patients. Operative outcomes were similarin the 2 populations but elderly patients had a greater complications rate (54.1 vs 42%; p = 0.005) and a higherrate (9.4 vs 4.2%; p = 0.0525) of infective complications. Indeed, multivariate analysis showed that age > 70yand positive stone culture were associated with a significantly higher rate of clinically-significant complications.Conclusions. Percutaneous nephrolithotomy proved to be effective in consecutive/unselected elderly (≥ 70y)candidates to such procedure but at the price of a greater risk of, mainly minor, complications. The higher incidence of infective complications speaks for potentially reduced immune response of such patients and setsthe rationale for further addressing this issue. ER -