TY - JOUR AU - Colaianni, G. AU - Colucci, S. AU - Cinti, S. AU - Grano, M. PY - 2016/09/15 Y2 - 2024/03/29 TI - Myokine Irisin recapitulates the effect of physical activity on bone and muscle tissues JF - JOURNAL OF GERONTOLOGY AND GERIATRICS JA - Gerontology and Geriatrics VL - 64 IS - 3 SE - Translational Research in Gerontology and Geriatrics - Reviews DO - UR - https://www.jgerontology-geriatrics.com/article/view/171 SP - 92-96 AB - The concomitant occurrence of osteoporosis and sarcopenia is very common during the process of aging andpathological conditions characterized by the disuse of the musculoskeletal system. However, to date there areno evidence about the mechanism responsible for the coupling of these two process.During the last decade, studies on the interactions between muscle and bone have made remarkable stepsforward, establishing that skeletal muscle is an endocrine organ producing and releasing myokines acting in aparacrine or endocrine fashion. Among these, the newly identified myokine Irisin, produced by skeletal muscleafter physical exercise, plays a key role in the bone-muscle functional unit, with a major impact on the skeletonby increasing cortical bone mineral density, modifying its geometry and improving bone strength. Furthermore,in vitro and in vivo studies reported an autocrine effect of Irisin on skeletal muscle and highlighted the autocrine myogenic potential of this myokine.This review summarizes new insights on the topic of Irisin action on bone and skeletal muscle, which supportthe hypothesis that Irisin may represent a novel molecular entity with exercise-mimetic properties. Hopefullyfuture research may expand the knowledge of its ability to improve bone integrity and muscle activity andcould pave the way for the use of Irisin as a new therapy for the prevention and treatment of musculoskeletaldisorders, particularly useful for those patients that are not capable of performing physical activity, such as theelderly or bedridden patients. ER -