TY - JOUR AU - Komici, K. AU - Rengo, G. AU - Leosco, D. AU - Ferrara, N. PY - 2017/09/15 Y2 - 2024/03/29 TI - Cardiac fibrosis in heart failure JF - JOURNAL OF GERONTOLOGY AND GERIATRICS JA - Gerontology and Geriatrics VL - 65 IS - 03 Special SE - Translational Research in Gerontology and Geriatrics - Reviews DO - UR - https://www.jgerontology-geriatrics.com/article/view/139 SP - 177-183 AB - The prevalence of heart failure is rising with poor prognosis and health costs. Cardiac remodeling is a cardinalprocess mediating the progression to heart failure, and cardiac fibroblasts play a critical role in the regulationof left ventricular remodeling mainly through the excessive extracellular matrix protein deposition and theirdifferentiation to a myofibroblast phenotype with excessive proliferative and migratory properties. All this characteristics are known also as cardiac fibrosis. This process is crucial for the structural integrity of myocardialtissue. After myocardial infarction, are activated two important type of cardiac fibrosis: reparative and reactivecardiac fibrosis. Both of them are mediated by a huge number of inflammatory and hormonal mediators. In thisreview we will focus on the role of three important systems involved in cardiac fibrosis and described as thegreat contributors in heart failure: inflammatory, RAA and beta-adrenergic system. The deeper understandingof these great contributors is of interest in the development of new therapeutic strategies toward cardiac fibrosis and heart failure. ER -