TY - JOUR AU - Ciarambino, T. AU - Paolo, C. AU - Giordano, M. PY - 2017/09/15 Y2 - 2024/03/29 TI - Age and frailty: are they related in decline of renal function? JF - JOURNAL OF GERONTOLOGY AND GERIATRICS JA - Gerontology and Geriatrics VL - 65 IS - 3 SE - Clinical Geriatrics - Reviews DO - UR - https://www.jgerontology-geriatrics.com/article/view/136 SP - 161-168 AB - The chronic kidney disease (CKD) is defined as abnormalities of kidney structure and/or function, present forat least 3 months, with implications for health. Incidence and prevalence differ between countries ranging from10 to 20%. In the Baltimore longitudinal studies, Lindeman et al. reported the rate of decline in renal functionwith aging. The average decline in clearance of creatinine (ClCr) was 0.75 ml/min/year. The prevalence of frailtyoverall among the Cardiovascular Health Study cohort was 7%, but when restricted to patients with CKD,the prevalence of frailty raised to 15%. However, presence of frailty during CKD was associated with abouta twofold higher risk for mortality. Because frailty and CKD are associated with age, poor clinical outcomes,falls, disability, hospitalization and mortality, it is important to identify the subjects at high risk and needing acomprehensive care in order to improve outcome for this vulnerable population. ER -