@article{Martorana_Motta_Koch_Massaia_Mondino_Raniero_Vacca_Di Lorenzo_Cavallo_Oddenino_Pavanelli_Maniscalco_Montano_Mastropietro_Bellia_Ciravegna_La Rocca_Vitale_Lorico_Zacchettin_Scalise_Codemo_Gabelli_Spano_Poli_Panuccio_Bruno_Alfieri_Ruggiero_Cursi_Levi della Vida_2018, title={Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study}, volume={66}, url={https://www.jgerontology-geriatrics.com/article/view/97}, abstractNote={<p><strong>Background &amp; Aims.</strong> This observational retrospective study aimed at evaluating the effects of one-year administration&nbsp;of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive<br>impairment.<br><strong>Methods</strong>. Patient’s demographic data and medical history are reported. Each patient performed brain imaging<br>and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of<br>homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental<br>State Examination (MMSE).<br><strong>Results</strong>. 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline<br>expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p &lt; 0.0001),<br>and in those with mMCI at month 4 (p &lt; 0.05).<br><strong>Conclusions. A</strong>dministration of homotaurine revealed beneficial effects in our sample population of MCI patients.<br>Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment<br>for cognitive symptoms. Further research is however needed to clarify whether this compound could<br>influence the progression of cognitive decline.</p&gt;}, number={1}, journal={JOURNAL OF GERONTOLOGY AND GERIATRICS}, author={Martorana, A. and Motta, c. and Koch, G. and Massaia, M. and Mondino, S. and Raniero, I. and Vacca, A. and Di Lorenzo, F. and Cavallo, G. and Oddenino, E. and Pavanelli, E. and Maniscalco, M. and Montano, V. and Mastropietro, A. and Bellia, N.C. and Ciravegna, E. and La Rocca, M. and Vitale, E. and Lorico, F. and Zacchettin, B. and Scalise, A. and Codemo, A. and Gabelli, C. and Spano, M. and Poli, S. and Panuccio, D. and Bruno, P. and Alfieri, P. and Ruggiero, R. and Cursi, F. and Levi della Vida, G.}, year={2018}, month={Mar.}, pages={15-20} }