@article{Lelli_Adiletta_Maddalena_Bisconti_Antonelli Incalzi_Pedone_2022, title={Role of PDW and MPV in stratification of heart failure severity in older adults}, volume={70}, url={https://www.jgerontology-geriatrics.com/article/view/491}, DOI={10.36150/2499-6564-N491}, abstractNote={<p><strong>Background &amp; Aims</strong>. Stratification of heart failure (HF) severity in older adults may be difficult. We hypothesized that mean platelet volume (MPV) and platelet distribution width (PDW) may serve as inflammation markers and used for this purpose. The objective of the study is to analyze the association between MPV/PDW and HF severity in older adults. <br><strong>Methods</strong>. in this retrospective cross-sectional study, we enrolled 415 patients aged ≥ 65 years admitted for acute HF to an Acute Geriatric Ward. Participants were stratified according to the diagnosis of HF with preserved (HFpEF, N: 250) or non-preserved (HFmrEF/HFrEF, N: 165) ejection fraction. The association with ejection fraction (EF), NT-proBNP, right ventricular function (TAPSE), and diastolic function was analyzed using linear or multinomial regression models. <br><strong>Results</strong>. mean age of the participants was 83.1 years (SD 7), 41.2% were male. MPV was positively associated with NT-proBNP in the total sample (Adjusted b: 0.16, p = 0.008) and in the HFmrEF/HFrEF group (Adjusted b: 0.215, p = 0.015), but not in the HFpEF group; no association was found with EF (analyzed only in HFmrEF/HFrEF group), or TAPSE. Using type I diastolic disfunction as reference, MPV was associated with an increased risk of monophasic pattern (Adj.OR: 1.44, 95% CI: 1.08-1.92) and III grade disfunction (Adj.OR: 1.54, 95% CI: 1.01- 2.35) in the total sample, and in the HFmrEF/HFrEF group (Monophasic Adj.OR: 2.51, 95% CI: 1.33-4.74; III grade Adj.OR: 4.77, 95% CI: 2.05- 11.1). Similar results were found analyzing PDW. <br><strong>Conclusions</strong>. MPV and PDW are inexpensive and simple potential markers of HFmrEF/HFrEF severity in older adults. Further studies are needed to clarify their classificatory and prognostic properties.</p&gt;}, number={3}, journal={JOURNAL OF GERONTOLOGY AND GERIATRICS}, author={Lelli, Diana and Adiletta, Veronica and Maddalena, Gaetano and Bisconti, Ilaria and Antonelli Incalzi, Raffaele and Pedone, Claudio}, year={2022}, month={May}, pages={178-186} }