@article{Conte_Petriglia_Grieco_Russo_Provenzano_Campana_Parisi_2019, title={Potential role of epicardial adipose tissue in the pathogenesis of calcific aortic stenosis}, volume={67}, url={https://www.jgerontology-geriatrics.com/article/view/41}, abstractNote={<p>Aortic stenosis (AS) is the most common valvular heart disease in industrialized countries, with a prevalence<br>that increases with age, and represents an important cause of morbidity, hospitalization and death in the elderly&nbsp;population.<br>It is widely recognized that AS is a progressive and active process that leads to calcific degeneration of the<br>aortic valve, involving complex and multifactorial pathological mechanisms, and including triggering factors<br>which lead to inflammation. In the last decades, several pieces of evidence have suggested a pathogenetic<br>role of the epicardial adipose tissue (EAT), the cardiac visceral fat depot, in the development and progression of<br>AS. EAT contributes to the inflammatory burden of AS through the secretion of numerous pro-inflammatory and<br>pro-atherogenic cytokines. Therefore, this review aims to explore the potential role of EAT in the pathogenesis<br>of AS and the potential therapeutic perspectives to slower AS progression.</p&gt;}, number={3 Suppl}, journal={JOURNAL OF GERONTOLOGY AND GERIATRICS}, author={Conte, M. and Petriglia, L. and Grieco, F.V. and Russo, C. and Provenzano, S. and Campana, P. and Parisi, V.}, year={2019}, month={Sep.}, pages={219-225} }