@article{Petraglia_Conte_Grieco_Ferrante_Russo_Parisi_2019, title={Epicardial adipose tissue in the pathogenesis and progression of coronary artery disease}, volume={67}, url={https://www.jgerontology-geriatrics.com/article/view/39}, abstractNote={<p>Coronary artery disease (CAD) represents one of the most important causes of morbility, hospitalization and<br>death, and its incidence greatly increases in the elderly population. In the last decades, several pieces of evidence&nbsp;have suggested a pathogenetic role of systemic and visceral fat inflammation in the development and<br>progression of CAD. The epicardial adipose tissue (EAT), the visceral fat depot of heart, produces and secretes<br>numerous pro-inflammatory mediators that could be involved in the pathogenesis of coronary atherosclerosis.<br>Furthermore, age-related low-grade inflammation leads to the accumulation and inflammation of EAT. Therefore,&nbsp;this review aims to explore the potential implication of EAT in the pathogenesis of CAD, the link between&nbsp;systemic inflammation and an EAT pro-inflammatory phenotype, and, finally the perspectives for novel therapeutic&nbsp;strategies targeting the cardiac visceral fat.</p&gt;}, number={3 Suppl}, journal={JOURNAL OF GERONTOLOGY AND GERIATRICS}, author={Petraglia, L. and Conte, M. and Grieco, F. V. and Ferrante, L. and Russo, C. and Parisi, V.}, year={2019}, month={Sep.}, pages={205-212} }