@article{Corrado_Sanpaolo_Rotondo_Cantatore_2019, title={Pattern of adipokine expression in osteoblasts from osteoporotic and osteoarthritic bone}, volume={67}, url={https://www.jgerontology-geriatrics.com/article/view/31}, abstractNote={<p><strong>Background and aims.</strong> Osteoarthritis (OA) and osteoporosis (OP) are the two most common osteo-articular<br>diseases in elderly population, whose etiopathogenesis is complex and multifactorial. An inverse relationship<br>between OA and OP has been observed and both diseases are characterized by apparently opposite changes<br>in bone quantity and quality. In vitro studies revealed that osteoblasts from OA and OP bone present different<br>phenotypes. Adipokines are involved in many physiological and pathological processes, including bone<br>homeostasis and osteo-articular diseases. The aim of this study is to evaluate the expression of various adipokines&nbsp;in osteoblasts deriving from healthy subjects and patients suffering from OA or OP.<br><strong>Methods</strong>. Primary human osteoblast cultures were obtained from healthy, OA, and OP subjects. In each cell<br>population the synthesis and gene expression of leptin, resistin and adiponectin were evaluated.<br><strong>Results</strong>. Adipokines showed an opposite patterns of adipokine expression in OA and OP osteoblasts. Leptin<br>and resistin synthesis and expression were higher in OA osteoblasts compared to healthy and OP osteoblasts,<br>while adiponectin synthesis and expression were significantly lower. Conversely, in OP osteoblasts a reduced<br>synthesis and expression of leptin and resistin were observed, concurrently with increased adiponectin expression.<br><strong>Conclusions</strong>. These data confirm that osteoblasts deriving from OA and OP are characterized by different<br>metabolic changes, consisting in opposite expression pattern of adipokines, and suggest that adipokines<br>could be involved in the pathogenesis of bone alterations in both diseases.</p&gt;}, number={4}, journal={JOURNAL OF GERONTOLOGY AND GERIATRICS}, author={Corrado, A. and Sanpaolo, E.R. and Rotondo, C. and Cantatore, F.P.}, year={2019}, month={Dec.}, pages={249-255} }