Effect of homotaurine in patients with cognitive impairment: results from an Italian observational retrospective study
Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administration
of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive
Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imaging
and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of
homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental
State Examination (MMSE).
Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline
expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001),
and in those with mMCI at month 4 (p < 0.05).
Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients.
Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment
for cognitive symptoms. Further research is however needed to clarify whether this compound could
influence the progression of cognitive decline.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018
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