Review - until March 2020
Published: 2018-12-15

Unmet clinical questions in elderly patients with locally advanced and metastatic bladder cancer

School of Biomedical Sciences, Etromapmax Pole, Lesina (FG), Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy
School of Biomedical Sciences, Etromapmax Pole, Lesina (FG), Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy
Laboratory of Pre-Clinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy
Department of Clinical and Experimental Medicine, University of Foggia, Italy
Department of Urology, Institut Montsouris, Paris, France
Laboratory of Pre-Clinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy
Bladder Cancer Chemotherapy Elderly patients

Abstract

Bladder cancer (BC) is a deadly disease with high prevalence in elderly population. Several therapeutic issues
are still unsolved in the clinical management of these patients. Radical surgery with or without perioperative
chemotherapy represents the best therapeutic strategy in early-stage disease even though recurrence rates
are high and few therapy options are available for recurrent patients. Platin-based chemotherapy is currently
the standard of care for advanced disease with a poor life expectancy of about 12 months. Novel therapeutic
options, including molecular-targeted agents and immunotherapy, are under preclinical and clinical evaluation
with promising results.
A major issue in BC care is the management of elderly patients, a population with relevant co-morbidities,
increased risk of life-threatening toxicities and currently not receiving the best therapy options. This review
summarizes literature data about treatment strategies in elderly BC patients and the relevance of geriatric
assessment to categorize fit patients who can receive standard therapies from unfit patients who should be
treated with extreme caution.

Affiliations

G. Pezzicoli

School of Biomedical Sciences, Etromapmax Pole, Lesina (FG), Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy

A. Ummarino

School of Biomedical Sciences, Etromapmax Pole, Lesina (FG), Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy

F. Maddalena

Laboratory of Pre-Clinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy

R. Villani

Department of Clinical and Experimental Medicine, University of Foggia, Italy

E. Barret

Department of Urology, Institut Montsouris, Paris, France

M. Landriscina

Laboratory of Pre-Clinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018

How to Cite

[1]
Pezzicoli, G., Ummarino, A., Maddalena, F., Villani, R., Barret, E. and Landriscina, M. 2018. Unmet clinical questions in elderly patients with locally advanced and metastatic bladder cancer. JOURNAL OF GERONTOLOGY AND GERIATRICS. 66, 4 (Dec. 2018), 253-259.
  • Abstract viewed - 30 times
  • PDF downloaded - 26 times