Prostatic inflammation is associated with benign prostatic hyperplasia rather than prostate cancer
Background and aims. The relationship between prostatic inflammation, benign prostatic hyperplasia and
prostate cancer is controversial. The present study aimed to determine the relationship between grade and
aggressiveness of prostatic inflammation and the risk of being diagnosed with prostate cancer.
Methods. Grade and aggressiveness of prostatic inflammation were assessed by Irani G and A scores, respectively,
in prostate biopsy specimens of men having undergone this procedure because of increased serum PSA
and/or digital rectal examination. We also assessed the correlation between Irani G and A scores and clinical
variables related to benign prostatic obstruction.
Results. Of the 1178 eligible patients, 615 (52.2%) were diagnosed with PCa; they were older, had greater
PSA, suspicious digital rectal examination and peak flow rate but lower post-void residual urine volume, prostate
volume and international prostate symptoms score than those without cancer. High-grade inflammation
(Irani G 2-3) was significantly more common in patients with benign prostate than in those with PCa and the
same applied to highly aggressive inflammation (Irani A 2-3). Indeed, patients with high-grade inflammation
had greater PSA, prostate volume, post-void residual and international prostate symptoms score, suggesting
high-grade inflammation to correlate with benign prostatic obstruction. Highly-aggressive inflammation conversely
correlated only with prostate volume.
Conclusions. Prostatic inflammation seems to be associated with benign prostatic hyperplasia rather than
prostate cancer, with benign prostatic obstruction being strictly linked to the degree of inflammation.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018
How to Cite
- Abstract viewed - 67 times
- PDF downloaded - 39 times