Clinical Geriatrics
Published: 2020-07-15

Sexual differences regarding Alzheimer’s disease: a narrative review

Medical Doctor, ASL Bari, Italy
Department of Surgery, University of Catania, Italy
Department of Internal Medicine, Hospital of F. Veneziale, ASREM, Italy
Department of Internal Medicine, Hospital of Savona, Italy
Hospital of Marcianise, ASL Caserta, Italy
Alzheimer disease gender differences dementia women gender related

Abstract

Background. Actually, there are about 5.2 million people with Alzheimer’s dementia (AD) in the USA, 3.3 million are women and 1.9 million are men. Objective. We will find out the status on the Alzheimer disease in relation to the brain structure, diagnosis, symptoms and therapy by gender. Methods. We analyzed, in this narrative review, the literature between 1989-2019 published on the Pubmed about Alzheimer disease and gender. The keywords were: Alzheimer disease and sex differences. Conclusions. Women over 80 years have a higher incidence of AD than men. Women have a faster age-related decline and are more likely to respond to donepezil and rivastigmina leading to less cognitive decline. At more advanced ages, women incurred greater costs than men of the same age. Woman gender could be a risk factor for evolution of AD. We will emphasize the importance of considering sex as a biological variable in the design of preclinical and clinical studies that investigate underlying pathologies or response to pharmacological interventions in AD.

Affiliations

Immacolata Ambrosino

Medical Doctor, ASL Bari, Italy

Marco Vacante

Department of Surgery, University of Catania, Italy

Cecilia Politi

Department of Internal Medicine, Hospital of F. Veneziale, ASREM, Italy

Elena Barbagelata

Department of Internal Medicine, Hospital of Savona, Italy

Tiziana Ciarambino

Hospital of Marcianise, ASL Caserta, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2020

How to Cite

[1]
Ambrosino, I., Vacante, M., Politi, C., Barbagelata, E. and Ciarambino, T. 2020. Sexual differences regarding Alzheimer’s disease: a narrative review. JOURNAL OF GERONTOLOGY AND GERIATRICS. (Jul. 2020). DOI:https://doi.org/10.36150/2499-6564-376.
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