Review
Published: 2020-06-15

The secretory senescence in otorhinolaryngology: principles of treatment

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy
Department of Sense Organs, Sapienza University of Rome, Italy
Department of Sense Organs, Sapienza University of Rome, Italy
Otolaryngology Department, Di Venere Hospital, Bari, Italy
Department of Neurosciences, Section of Otolaryngology and Regional Centre for Head and Neck Cancer, University of Padua, Treviso, Italy
Department of Medicine and Surgery, University of Salerno, Italy
Otorhinolaryngology Head and Neck Surgery, University Hospital of Verona Borgo Trento, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Italy
Head and Neck Oncology and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Italy
Otolaryngology Head and Neck Surgery Unit of “Azienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi”, Naples, Italy
Department of Sense Organs, Sapienza University of Rome, Italy
Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy; 11 Department of medicine, surgery and dentistry- university of Salerno , Italy
Department of medicine, surgery and dentistry- university of Salerno , Italy
Mocella12,
Otolaryngology Unit, Mons. Dimiccoli Hospital, Barletta, Italy
Otolaryngology Unit, Mons. Dimiccoli Hospital, Barletta, Italy
Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy
Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy
secretory senescence xerostomia geriatric rhinitis cell senescence dysphagia gene therapy nutraceuticals

Abstract

Atrophy or hypofunction of the salivary gland because of aging, radiotherapy or disease causes hyposalivation and impairs the quality of life of patients by compromising mastication, swallowing and speech and by leading to a loss of taste. Moreover, hyposalivation exacerbates dental caries and induces periodontal disease, and oral candidiasis. Currently, no satisfactory therapies have been established to solve salivary hypofunction. Current treatment options for atrophy or hypofunction of the salivary glands in clinical practice are only symptomatic and include saliva substitutes and parasympathetic agonists, such as pilocarpine, to stimulate salivary flow. However, parasympathomimetics have systemic side effects, so different treatment options are necessary, and research has recently focused on this. The main strategies that have been proposed to restore salivary gland atrophy and hypofunction are gene therapy by gene activation/silencing during stem cell differentiation and by the use of viral vectors, such as adenoviruses; cell-based therapy with salivary gland cells, stem cells and non-salivary gland and/ or non-epithelial cells to regenerate damaged salivary gland cells; replacement with tissue bioengineering in which organoids from pluripotent stem cells are used in the development of organ replacement regenerative therapy. Remarkable progression in this research field has been made in the last decade, but a definitive therapy for salivary gland hypofunction has not been developed due to intrinsic challenges that come with each approach. However, with research efforts in the future, a range of precision medicine therapies may become available individualized to each patient.

Affiliations

Valeria Marrosu

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Filippo Carta

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Daniela Quartu

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Melania Tatti

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Cinzia Mariani

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Daniele De Seta

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Roberto Puxeddu

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Italy

Diletta Angeletti

Department of Sense Organs, Sapienza University of Rome, Italy

Flaminia Campo

Department of Sense Organs, Sapienza University of Rome, Italy

Paolo Petrone

Otolaryngology Department, Di Venere Hospital, Bari, Italy

Giacomo Spinato

Department of Neurosciences, Section of Otolaryngology and Regional Centre for Head and Neck Cancer, University of Padua, Treviso, Italy

Alfonso Scarpa

Department of Medicine and Surgery, University of Salerno, Italy

Gabriele Molteni

Otorhinolaryngology Head and Neck Surgery, University Hospital of Verona Borgo Trento, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Italy

Giuditta Mannelli

Head and Neck Oncology and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Italy

Pasquale Capasso

Otolaryngology Head and Neck Surgery Unit of “Azienda Ospedaliera di Rilievo Nazionale dei Colli, Ospedale Monaldi”, Naples, Italy

Massimo Ralli

Department of Sense Organs, Sapienza University of Rome, Italy

Valentina Casoli

Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy; 11 Department of medicine, surgery and dentistry- university of Salerno , Italy

Francesco Antonio Salzano

Department of medicine, surgery and dentistry- university of Salerno , Italy

Stelio Antonio Mocella

Mocella12,

Francesco Barbara

Otolaryngology Unit, Mons. Dimiccoli Hospital, Barletta, Italy

Salvatore Dadduzio

Otolaryngology Unit, Mons. Dimiccoli Hospital, Barletta, Italy

Anna Berardi

Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy

Carlo Berardi

Otolaryngology Department, Istituto Clinico Città Studi, Milan, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2020

How to Cite

[1]
Marrosu, V., Carta, F., Quartu, D., Tatti, M., Mariani, C., De Seta, D., Puxeddu, R., Angeletti, D., Campo, F., Petrone, P., Spinato, G., Scarpa, A., Molteni, G., Mannelli, G., Capasso, P., Ralli, M., Casoli, V., Salzano, F.A., Mocella, S.A., Barbara, F., Dadduzio, S., Berardi, A. and Berardi, C. 2020. The secretory senescence in otorhinolaryngology: principles of treatment. JOURNAL OF GERONTOLOGY AND GERIATRICS. 68, 02 Special (Jun. 2020), 113-121. DOI:https://doi.org/10.36150/2499-6564-489.
  • Abstract viewed - 80 times
  • PDF downloaded - 17 times