Clinical, drugs interactions and pharmacogenetics evaluation of Warfarin treatment in an elderly patient: a case report
Introduction. Cardiovascular diseases are very prevalent in the elderly population and characterized by high
complexity, poor prognosis and comorbidity. Atrial fibrillation is common in elderly patients both in institutionalized
in long-term care facilities and in community associated or not to congestive heart failure, but the management
with anticoagulant oral therapy is highly variable and problematic.
Case presentation. Here we describe a case report on a patient treated with amiodarone and heparine for
acute atrial fibrillation episodes. Three years before he underwent partial intestinal resection for bowel cancer.
During Warfarin therapy a treatment with neomycin sulphate/bacitracin was started. After three days of Warfarin
therapy an International Normalised Ratio (INR) value > 10 was found. No bleeding occurred, but the period
of hospitalization was prolonged. After genotype assessment for CYP2C9 and VKORC1 he was found to be an
intermediate metabolizer with the genotype of CYP2C9*1/*2, and homozygous for VKORC1*2/*2. By using the
International Warfarin Pharmacogenetics Consortium algorithm, the estimated therapeutic Warfarin dose was
1.8 mg/day, less than a half of prescribed dose.
Conclusion. A preventive pharmacogenetic assessment could be very useful in defining the right dose of
Warfarin to be administered especially in elderly patients institutionalized in long-term care facilities with comorbidity
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© Società Italiana di Gerontologia e Geriatria (SIGG) , 2016
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