Review
Published: 2017-06-15

Bisphosphonates and osteoarthritis

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy
Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy
Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy
Bisphosphonates Osteoblast Osteoclast Osteoarthritis Inflammation

Abstract

Osteoarthritis (OA) is the most common degenerative joint disease; it represents a major public health problem
and is ranked among the top 10 causes of disability worldwide, especially in elderly subjects. Although
the main characteristic of OA is the progressive degeneration and loss of joint cartilage, it is now commonly
accepted that all the articular components are involved, as the structural alterations observed in OA include
sub-chondral bone changes, osteophyte formation, variable degrees of synovial inflammation, degeneration of
ligaments and hypertrophy of the joint capsule. There are currently no treatments that delay or halt OA progression;
in general, therapeutic agents that modulate the cellular activities in individual joint tissues such as bone,
cartilage or synovium have proven to be effective in arresting or slowing the progression of joint pathology in
animal models of OA. Particularly, bisphosphonates may determine some positive structural and symptomatic
effects in the treatment of OA through different mechanisms, including their ability to modify osteoclast and
osteoblast metabolism in the sub-chondral bone and to inhibit the synovial inflammatory changes.

Affiliations

A. Corrado

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

N. Maruotti

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

F.P. Cantatore

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Corrado, A., Maruotti, N. and Cantatore, F. 2017. Bisphosphonates and osteoarthritis. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 2 (Jun. 2017), 124-129.
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