Review
Published: 2017-06-15

From redox proteomics to clinical practice: search for therapeutic targets

Department of Biochemical Sciences, Sapienza University of Rome, Italy
Department of Biochemical Sciences, Sapienza University of Rome, Italy
Department of Biochemical Sciences, Sapienza University of Rome, Italy
Alzheimer disease Protein oxidation Antioxidant Protein aggregation Chaperones

Abstract

Alzheimer disease (AD) is the most common form of dementia in the elderly population, characterized by a
gradual deterioration of memory and other cognitive functions. The major pathological characteristics of AD
brains are the presence of senile plaques, made of amyloid β-peptide (Aβ), neurofibrillary tangles, composed
of hyperphosphorylated tau protein, and neuronal loss. Among putative mechanisms responsible of neurodegeneration,
several studies demonstrated the role of oxidative stress as an important factor contributing to
the initiation and progression of AD. If from one side disruption of redox balance and increased production of
free radicals are likely to be related to mitochondria dysfunction and/or aberrant accumulation of misfolded
proteins, on the other side the abnormal accumulation of Aβ and tau proteins appears to promote the redox
imbalance. In addition, evidence has suggested that oxidative stress may augment the production and aggregation
of Aβ and facilitate the phosphorylation and polymerization of tau, thus forming a vicious cycle that
promotes the initiation and progression of AD.
Taken together, these findings suggest that therapeutic strategies aimed at preventing/reducing oxidative
stress-mediated damage may be effective for the treatment of AD and other neurodegenerative disorders.

Affiliations

F. Di Domenico

Department of Biochemical Sciences, Sapienza University of Rome, Italy

C. Cini

Department of Biochemical Sciences, Sapienza University of Rome, Italy

M. Perluigi

Department of Biochemical Sciences, Sapienza University of Rome, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Di Domenico, F., Cini, C. and Perluigi, M. 2017. From redox proteomics to clinical practice: search for therapeutic targets. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 2 (Jun. 2017), 101-109.
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