Review
Published: 2017-09-15

Therapy response variability in elder cardiac patients

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy
Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy
Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy
Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy
Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy; Association no profit F.I.R.S. Thermae (Interdisciplinary Training, Researches and spa Sciences), Bacoli, Naples, Italy
Association no profit F.I.R.S. Thermae (Interdisciplinary Training, Researches and spa Sciences), Bacoli, Naples, Italy
Cardiovascular drugs Pharmacogenetics Anticoagulant Antiplatelet agents Non-pharmacological treatments

Abstract

Cardiovascular drugs are among the most prescribed medications in the world and, despite their proven effectiveness,
there is a large variability in the therapeutic response in term of both efficacy and tolerability with
remarkable clinical consequences especially in elderly patients. Additionally, cardiovascular patients respond
in a changing manner also to non-pharmacological therapeutic approaches, such as antioxidants supplementation
and exercise training. This review focuses on factors, including biochemical and molecular variables,
comorbidity, polypharmacy and life-style that may influence the response to the common cardiovascular pharmacological
and non-pharmacological treatments, paying particular attention to the emergent issue of cardiovascular
pharmacogenetics.

Affiliations

V. Conti

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy

T. Iannaccone

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy

V. Manzo

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy

P. Malangone

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy

M. Costantino

Department of Medicine, Surgery and Dentistry, University of Salerno-Baronissi, Italy; Association no profit F.I.R.S. Thermae (Interdisciplinary Training, Researches and spa Sciences), Bacoli, Naples, Italy

A. Filippelli

Association no profit F.I.R.S. Thermae (Interdisciplinary Training, Researches and spa Sciences), Bacoli, Naples, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Conti, V., Iannaccone, T., Manzo, V., Malangone, P., Costantino, M. and Filippelli, A. 2017. Therapy response variability in elder cardiac patients. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 03 Special (Sep. 2017), 212-222.
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