Review - until March 2020
Published: 2017-09-15

Cardiac fibrosis in heart failure

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Cardiac fibrosis Cardiac fibroblasts Cytokines RAA system Beta-adrenergic receptors

Abstract

The prevalence of heart failure is rising with poor prognosis and health costs. Cardiac remodeling is a cardinal
process mediating the progression to heart failure, and cardiac fibroblasts play a critical role in the regulation
of left ventricular remodeling mainly through the excessive extracellular matrix protein deposition and their
differentiation to a myofibroblast phenotype with excessive proliferative and migratory properties. All this characteristics
are known also as cardiac fibrosis. This process is crucial for the structural integrity of myocardial
tissue. After myocardial infarction, are activated two important type of cardiac fibrosis: reparative and reactive
cardiac fibrosis. Both of them are mediated by a huge number of inflammatory and hormonal mediators. In this
review we will focus on the role of three important systems involved in cardiac fibrosis and described as the
great contributors in heart failure: inflammatory, RAA and beta-adrenergic system. The deeper understanding
of these great contributors is of interest in the development of new therapeutic strategies toward cardiac fibrosis
and heart failure.

Affiliations

K. Komici

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

G. Rengo

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

D. Leosco

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

N. Ferrara

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Komici, K., Rengo, G., Leosco, D. and Ferrara, N. 2017. Cardiac fibrosis in heart failure. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 03 Special (Sep. 2017), 177-183.
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