Review - until March 2020
Published: 2017-09-15

Age and frailty: are they related in decline of renal function?

Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy
Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy
Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy
Renal Age Frailty Elderly

Abstract

The chronic kidney disease (CKD) is defined as abnormalities of kidney structure and/or function, present for
at least 3 months, with implications for health. Incidence and prevalence differ between countries ranging from
10 to 20%. In the Baltimore longitudinal studies, Lindeman et al. reported the rate of decline in renal function
with aging. The average decline in clearance of creatinine (ClCr) was 0.75 ml/min/year. The prevalence of frailty
overall among the Cardiovascular Health Study cohort was 7%, but when restricted to patients with CKD,
the prevalence of frailty raised to 15%. However, presence of frailty during CKD was associated with about
a twofold higher risk for mortality. Because frailty and CKD are associated with age, poor clinical outcomes,
falls, disability, hospitalization and mortality, it is important to identify the subjects at high risk and needing a
comprehensive care in order to improve outcome for this vulnerable population.

Affiliations

T. Ciarambino

Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy

C. Paolo

Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy

M. Giordano

Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Hospital Marcianise, Caserta, Italy, Università degli Studi della Campania, L. Vanvitelli, Naples, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Ciarambino, T., Paolo, C. and Giordano, M. 2017. Age and frailty: are they related in decline of renal function?. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 3 (Sep. 2017), 161-168.
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