Short Communication
Published: 2017-09-15

Bisphosphonates and osteoblast function

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy
Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy
Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

Abstract

Biphosphonates (BPs) are pharmacological agents widely used in clinical practice for the treatment of diseases characterized by increased bone remodeling, such as osteoporosis. Their main biological effect is the inhibition of osteoclast formation, maturation and activity, resulting in a strong inhibition of bone reabsorption processes. Nevertheless, there is increasing evidence that BPs can act not only through a direct action on osteoclasts, but also by an indirect effect mediated by osteoblasts, which may represent an alternative target and could be required for the complete anti-absorptive effects of these drugs. (...)

Affiliations

A. Corrado

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

E.R. Sanpaolo

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

F.P. Cantatore

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Corrado, A., Sanpaolo, E. and Cantatore, F. 2017. Bisphosphonates and osteoblast function. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 3 (Sep. 2017), 150-151.
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