Review
Published: 2017-12-15

aquatic organism as time machine: Nothobranchius furzeri

Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Napoli, Italy
Animal models for ageing Nothobranchius furzeri African turquoise kill fish life span Eastern Africa

Abstract

Background. There is need for animal models to study ageing. Worms, flies and mice have been extensively
explored with outstanding results.
Aims. Many studies have used Nothobranchius furzeri - the African turquoise killfish with a lifespan less than
1 year.
Results. Studies have shown that the ageing process of N. furzeri and humans share many features.
Discussion. Despite its relatively short lifespan for a vertebrate, N. furzeri shows many molecular, cellular and
physiological ageing phenotypes, shared with many other organisms, including humans. We have shown a
significant impairment of learning performance with age, when tested using an active avoidance task.
Conclusion. N. furzeri is an ideal model to explore – in short time – molecular mechanisms that control ageing
in vertebrates, including humans.

Affiliations

L. D’Angelo

Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Napoli, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
D’Angelo, L. 2017. aquatic organism as time machine: Nothobranchius furzeri. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 04 Special (Dec. 2017), 307-310.
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