An aquatic organism as time machine: Nothobranchius furzeri
Background. There is need for animal models to study ageing. Worms, flies and mice have been extensively
explored with outstanding results.
Aims. Many studies have used Nothobranchius furzeri - the African turquoise killfish with a lifespan less than
Results. Studies have shown that the ageing process of N. furzeri and humans share many features.
Discussion. Despite its relatively short lifespan for a vertebrate, N. furzeri shows many molecular, cellular and
physiological ageing phenotypes, shared with many other organisms, including humans. We have shown a
significant impairment of learning performance with age, when tested using an active avoidance task.
Conclusion. N. furzeri is an ideal model to explore – in short time – molecular mechanisms that control ageing
in vertebrates, including humans.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017
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