The interplay between fascia, skeletal muscle, nerves, adipose tissue, inflammation and mechanical stress in musculo-fascial regeneration| JOURNAL OF GERONTOLOGY AND GERIATRICS
Vol. 65: ISSUE 4 - DICEMBER 2017
Translational Research in Gerontology and Geriatrics - Reviews
Submitted: 2020-02-03
Published: 2017-12-15
PDF

The interplay between fascia, skeletal muscle, nerves, adipose tissue, inflammation and mechanical stress in musculo-fascial regeneration

Department of Sciences and Technologies, University of Sannio, Benevento, Italy; CEINGE Advanced Biotechnologies, s.c.a r.l, Napoli, Italy
Department of Sciences and Technologies, University of Sannio, Benevento, Italy
Neurophysiological muscle laboratory, Department of Neurosurgery, Ulm University, Guenzburg, Germany
School of Clinical Sciences & Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia
Laboratory for Innovation and Analysis of Bio- Performance, École Polytechnique de Montréal, Succursale Centre-Ville Montréal, Quebec, Canada
Neurophysiological muscle laboratory, Department of Neurosurgery, Ulm University, Guenzburg, Germany
Skeletal muscle Fascia, Musculo-fascial regeneration Extracellular matrix Muscle loading Muscle innervation Intramuscular adipose tissue

Abstract

Muscle and connective tissues are structures that provide stability and movement to organisms belonging to
the animal kingdom. Fascia and muscle tissues structurally and functionally integrate to form a musculofascial
system with exceptional biomechanical properties, which allow animals to accomplish complex tasks.
Mechanical overload through intense exercise or injury, however, may damage these tissues over the course
of a lifetime. Although mammalian skeletal muscle and fascia both retain a good regenerative potential in the
adulthood, regeneration is very sensitive to alterations in the biochemical and physical environment. In this review, the reciprocal role of fascial tissue and skeletal muscle in their regeneration processes are explored. The
involvement of adipose and nervous tissue in the regulation of muscle and fascia regeneration are also revised.
It is hypothesised, for the first time, that for effective regeneration of skeletal muscle, both muscle and fascial
tissues are necessary, and that nervous and adipose tissues contribute and deeply influence this process.

Affiliations

A. Zullo

Department of Sciences and Technologies, University of Sannio, Benevento, Italy; CEINGE Advanced Biotechnologies, s.c.a r.l, Napoli, Italy

F.P. Mancini

Department of Sciences and Technologies, University of Sannio, Benevento, Italy

R. Schleip

Neurophysiological muscle laboratory, Department of Neurosurgery, Ulm University, Guenzburg, Germany

S. Wearing

School of Clinical Sciences & Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia

L. Yahia

Laboratory for Innovation and Analysis of Bio- Performance, École Polytechnique de Montréal, Succursale Centre-Ville Montréal, Quebec, Canada

W. Klingler

Neurophysiological muscle laboratory, Department of Neurosurgery, Ulm University, Guenzburg, Germany

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Zullo, A., Mancini, F., Schleip, R., Wearing, S., Yahia, L. and Klingler, W. 2017. The interplay between fascia, skeletal muscle, nerves, adipose tissue, inflammation and mechanical stress in musculo-fascial regeneration. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 4 (Dec. 2017), 271-283.
  • Abstract viewed - 346 times
  • PDF downloaded - 188 times