Review
Published: 2017-12-15

Statins in cardiovascular prevention in the oldest-old. A black hole

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; San Raffaele Roma Open University, Rome, Italy
Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy
Cholesterol Statins Cardiovascular risk Elderly

Abstract

Elderly population is increasing rapidly together with the incidence of cardiovascular diseases (CVDs) and
cardiovascular (CV) mortality. The evaluation of total CV risk is necessary for prevention of CV events, but the
most used assessment tools do not include the elderly population. Among CV risk factors, hypercholesterolemia
increases with the age, but the results about the association between total cholesterol (TC) levels and
mortality in the elderly population are controversial. Statins are the first-choice drug for lipid-lowering therapy
in the elderly due to their efficacy and safety. In primary prevention there are no recommendations to the use
of statins in older adults because they do not reduce the risk of CV and all-cause mortality. On the contrary,
statin treatment is recommend both in older than in younger people in secondary prevention because of the
reduction of CV and all-causes mortality. High-intensity statins are more effective in the elderly population,
but these dosages are associated to an increased incidence of adverse reactions, especially liver dysfunction.
Finally, the degree of clinical frailty is inversely related to total cholesterol in the elderly and, accordingly, lower
cholesterol levels are associated to higher mortality in this population. There are no studies that specifically
evaluated the benefit of lipid-lowering therapy in severely frail older adults and a narrative-based approach,
instead of an evidence-based one, has been used to choose the better treatment plan.

Affiliations

I. Liguori

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

L. Aran

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

G. Bulli

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

G. Russo

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

F. Curcio

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

G. Sasso

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

F. Pirozzi

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

D. Della -Morte

Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; San Raffaele Roma Open University, Rome, Italy

G. Gargiulo

Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy

G. Testa

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy

F. Cacciatore

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy

D. Bonaduce

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

P. Abete

Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2017

How to Cite

[1]
Liguori, I., Aran, L., Bulli, G., Russo, G., Curcio, F., Sasso, G., Pirozzi, F., Della -Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D. and Abete, P. 2017. Statins in cardiovascular prevention in the oldest-old. A black hole. JOURNAL OF GERONTOLOGY AND GERIATRICS. 65, 4 (Dec. 2017), 263-270.
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