Original investigation
Published: 2018-06-15

Effectiveness of a specific nutritional supplement on cognitive, behavioral and functional symptoms in mild cognitive impairment and Alzheimer’s dementia: caregivers judgments. Results of an observational survey

Medicine and Rehabilitation Department, S. Anna Hospital, Gruppo San Donato, Brescia, Italy; Geriatric Research Group, Brescia, Italy
Alzheimer Regional Centre, G. Casati Hospital, ASST Rhodense, Rho, Italy
Alzheimer Regional Centre, G. Casati Hospital, ASST Rhodense, Rho, Italy
Medicine and Rehabilitation Department, S. Anna Hospital, Gruppo San Donato, Brescia, Italy; Geriatric Research Group, Brescia, Italy
Geriatric Research Group, Brescia, Italy
Nutritional supplement Mild cognitive impairment Alzheimer disease Caregivers

Abstract

Background and aims. Caregivers play a central role in the evaluation of symptoms in mild cognitive impairment
(MCI) and dementia, and in clinical practice their opinion is important in the definition of the effectiveness
of pharmacological and not pharmacological intervention.
With the aim to explore the impact of a nutritional intervention by the use of a medical food on quality of life,
cognitive and functional outcomes in large populations of Alzheimer’s dementia (AD) and MCI subjects, we
performed an observational survey (the MEMENTO study).
Methods. The study was carried out in 30 Italian outpatients clinics, based on patient and caregiver judgment.
Results. Five hundred patients (58.8% female, mean age 75.9 ± 7.1 SD) were included in the survey. The
results confirmed the data from RCT about the effectiveness of dietary supplementation with a medical food
on cognitive symptoms of AD and MCI and also the effectiveness on behavioral and functional deficits. In particular,
the effectiveness was more evident in patients with higher MMSE score, and in MCI compared to AD.
Interestingly, caregivers of MCI subjects reported better results than those of AD patients only in cognitive and
functional domains but not in behavioral domain.
Conclusions. The study uses for the first time the subjective judgment of patients and caregivers as an outcome
measure, by focusing on the cognitive aspects, and on functional status and behavior.

Affiliations

a. Bianchetti

Medicine and Rehabilitation Department, S. Anna Hospital, Gruppo San Donato, Brescia, Italy; Geriatric Research Group, Brescia, Italy

d. Perotta

Alzheimer Regional Centre, G. Casati Hospital, ASST Rhodense, Rho, Italy

l. Cravello

Alzheimer Regional Centre, G. Casati Hospital, ASST Rhodense, Rho, Italy

P. Ranieri

Medicine and Rehabilitation Department, S. Anna Hospital, Gruppo San Donato, Brescia, Italy; Geriatric Research Group, Brescia, Italy

M. Trabucchi

Geriatric Research Group, Brescia, Italy

Copyright

© Società Italiana di Gerontologia e Geriatria (SIGG) , 2018

How to Cite

[1]
Bianchetti, a., Perotta, d., Cravello, l., Ranieri, P. and Trabucchi, M. 2018. Effectiveness of a specific nutritional supplement on cognitive, behavioral and functional symptoms in mild cognitive impairment and Alzheimer’s dementia: caregivers judgments. Results of an observational survey. JOURNAL OF GERONTOLOGY AND GERIATRICS. 66, 02 Special (Jun. 2018), 68-74.
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