Micropapillary bladder cancer, a variant histology of the elderly

F. Sanguedolce 1, A. Cormio 2, B. Calò 3, M. Landriscina 4, E. Carvalho-Dias 5, L. Cormio 3

1 Section of Pathology, Department of Clinical and Experimental Medicine, University of Foggia, Italy; 2 Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy; 3 Urology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy; 4 Medical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy; 5 Urology Department, Hospital de Braga ICVS, University of Minho, Braga, Portugal

Micropapillary bladder cancer is a rare variant of bladder cancer with dismal biological behavior. It most frequently affects the elderly and it is essential to define and report its morphological features at pathology since it demonstrates poor response to conventional treatments. This review aims to systematically explore and critically appraise the current state of the evidence regarding clinical features, pathology issues, prognostic factors and therapeutic perspectives in this difficult and peculiar variant of bladder cancer. 

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