Bisphosphonates and osteoblast function

A. Corrado, E.R. Sanpaolo, F.P. Cantatore

Rheumatology Clinic Department of Medical and Surgical Sciences, University of Foggia, Italy

Biphosphonates (BPs) are pharmacological agents widely used in clinical practice for the treatment of diseases characterized by increased bone remodeling, such as osteoporosis. Their main biological effect is the inhibition of osteoclast formation, maturation and activity, resulting in a strong inhibition of bone reabsorption processes. Nevertheless, there is increasing evidence that BPs can act not only through a direct action on osteoclasts, but also by an indirect effect mediated by osteoblasts, which may represent an alternative target and could be required for the complete anti-absorptive effects of these drugs.

Download PDF