Background. There is need for animal models to study ageing. Worms, flies and mice have been extensively explored with outstanding results.
Aims. Many studies have used Nothobranchius furzeri – the African turquoise killfish with a lifespan less than 1 year.
Results. Studies have shown that the ageing process of N. furzeri and humans share many features.
Discussion. Despite its relatively short lifespan for a vertebrate, N. furzeri shows many molecular, cellular and physiological ageing phenotypes, shared with many other organisms, including humans. We have shown a significant impairment of learning performance with age, when tested using an active avoidance task.
Conclusion. N. furzeri is an ideal model to explore – in short time – molecular mechanisms that control ageing in vertebrates, including humans.