Age, mitochondria and bladder cancer

A. Cormio 1, C. Musicco 2, V. Pesce 1, R. Villani 3, A. Antonelli 4, E. Barret 5

1 Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy; 2 CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy; 3 Department of Clinical and Experimental Medicine, University of Foggia, Italy; 4 Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Urology Unit, ASST-Ospedali Civili, Brescia, Italy; 5 Department of Urology, Institut Montsouris, Paris, France

Bladder cancer (BC) is a major cause of mortality worldwide. Risk factors for BC development are male gender, age and exposure to carcinogens and especially cigarette smoking. Since it is not clearly understood why aging is an important BC risk factor, in this review we try to find common features between BC and aging. Evidence suggest that oxidative stress and mitochondrial dysfunction may link aging to BC, thus opening new perspectives in terms of preventive measures and novel potential therapeutic targets.

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