The chronic kidney disease (CKD) is defined as abnormalities of kidney structure and/or function, present for at least 3 months, with implications for health. Incidence and prevalence differ between countries ranging from 10 to 20%. In the Baltimore longitudinal studies, Lindeman et al. reported the rate of decline in renal function with aging. The average decline in clearance of creatinine (ClCr) was 0.75 ml/min/year. The prevalence of frailty overall among the Cardiovascular Health Study cohort was 7%, but when restricted to patients with CKD, the prevalence of frailty raised to 15%. However, presence of frailty during CKD was associated with about a twofold higher risk for mortality. Because frailty and CKD are associated with age, poor clinical outcomes, falls, disability, hospitalization and mortality, it is important to identify the subjects at high risk and needing a comprehensive care in order to improve outcome for this vulnerable population.