Background and aims. There is evidence for the ability of antioxidants to counteract the effects of inflammation. We aimed to determine whether the administration of a lycopene/olives vegetation water compound might reduce prostatic inflammation and consequent lower urinary tract symptoms in patients with histologically proven prostatic inflammation.
Methods. Over a month period, patients having undergone prostate biopsy and having been diagnosed with benign prostate were given lycopene/olives vegetarian water compound (Group A). Data were compared with those of a matched population of patients who did not receive such treatment (Group B). International prostate symptom score, peak flow rate and post-void residual were recorded before and at the end of treatment.
Results. The 17 patients in group A and the 17 in group B, had similar age, PSA, prostate volume, peak flow rate and post-void residual, but patients in Group A had lower median international prostate symptoms score than those in group B (7 vs 12; p = 0.012). All patients in group A successfully completed treatment with no side effect. Group B experienced no difference in international prostate symptoms score, peak flow rate and post-void residual whereas group A experienced no difference in peak flow rate, a slight reduction in post-void residual and a decrease in international prostate symptoms score. Most important, reduction in international prostate symptoms score was significantly higher in group A than in group B (-2.0 vs 0, respectively; p = 0.0004).
Conclusions. The lycopene/olives vegetation water compound seems to be effective in counteracting lower urinary tract symptoms due to prostatic inflammation.